Tuesday, September 30, 2025

Good Meds in the Armageddon Pharmacy—Saccharin?

Seriously?!

I know that’s what you’re thinking.  Believe me, I was too.

And so, I did a lot more research before daring to present the results here.

The research is shared in the ground-breaking EMBO Molecular Medicine article:  Saccharin Disrupts Bacterial Cell Envelop Stability and Interferes with DNA Replication Dynamics.

And what did that research show?

  • Saccharin in a 2.66% concentration inhibited the growth of A. baumanii[1]
  • Oral saccharin intake decreases the intestinal bacterial count and reduces acute and chronic colitis in mice.[2]
  • Colitis was improved in mice after therapeutic and prophylactic treatment with saccharin.[3] 
  • Previous studies showed that saccharin has antimicrobial activity—it kills bacteria.

·       What’s more, the research also showed that sucralose, aspartame, and acesulfame potassium exert a similar effect. 

·       The effects were more pronounced with Gram-negative Escherichia coli and Klebsiella pneumoniae, and with the Gram-positive Bacillus subtilis.

What’s been interesting, at least to me, is that the media (and then, by extension, the public) have been quick to pick up on the “saccharin is an antibiotic” topic.  And they’ve basically ignored previous studies showing the opposite, that saccharin is more likely to increase antibiotic resistance.  And that other less common artificial sweeteners also exhibited similar effects (positive and negative).[4] 

More research needs to be conducted.  Perhaps saccharin really does exhibit antibiotic effects whether taken internally or applied topically.  And perhaps not.  Maybe it’s something to keep in mind.  Something to suggest to others if they’ve run out of everything else and want to use your stuff.  Tell them to try their own saccharin instead.  Maybe try a little study on yourself and mix a packet of saccharin into a “hydrogel” as used in the study cited above, or perhaps some aloe vera gel and apply it to a wound.  Then see what happens. 

And perhaps the best course is not to blindly take advice from someone on social media.  (And for the record, that also includes me.)  That person may be jumping the gun a bit, using one study to make a broad claim. We've all got to be a bit more diligent and do our own research.



[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9832836/#emmm202216397-sec-0013

[2] https://pubmed.ncbi.nlm.nih.gov/32316544/

[3] https://pubmed.ncbi.nlm.nih.gov/32316544/

[4] https://www.sciencedirect.com/science/article/abs/pii/S030438942200629X?via%3Dihub

Monday, September 29, 2025

Medicinal Uses of Elecampane (Inula helenium)

Before getting into today's topic, I want to share that my interview with AC and Chris of Stakeholder Prepping aired yesterday.  You can listen on Spotify

https://open.spotify.com/show/1S50vyajR2NP0SP6dmTIAK?si=7egd3_2oSC6e0GNXYq9CbA

or at StakeholderPrepping.com.  Chris and AC have several of my books to give away to new listeners, and they also share a discount code for titles purchased through my new author website and store.  

Asteraceae family

Several years ago, I bought some elecampane seeds because the herb came highly recommended.  And then I didn’t plant them.  So, I eventually tired of storing them with the other seeds in the refrigerator and threw them onto the soil.  Where they proceeded to grow.  Slowly.  Our patience was finally rewarded with the appearance of the yellow flowers, somewhat like a yellow daisy, but with a lot more petals that are thinner.

This perennial plant grows wild from Minnesota and Missouri eastward, and from North Carolina to the north.  The botanical name comes from Helen of Troy, who reportedly carried elecampane when she departed for Troy.  The root is particularly good for respiratory conditions.

HARVEST

Two-year-old roots are the most medicinal.[1]  Dig the roots in the fall, cut them up, and dry at a high temperature.[2] 

PHARMACOLOGICAL PROPERTIES

EFFECTIVE AGAINST

  • Bacteria
    • MRSA[18]
    • Mycobacterium tuberculosis[19]
  • Fungi
  • Parasites

PREPARATIONS

  • Infusion: 1 heaping teaspoon of rootstock in 1 cup water, taken 1-2 times per day. May sweeten with honey. 
  • Glycerite:  dried root, 1:8, 1 teaspoon 3 times per day[23] 
  • Tincture:  fresh root, 1:2, 60% alcohol[24] to 75% alcohol[25]; dried root 1:5, 60% alcohol.[26] [27]  Dosage is 10-30 drops up to 4 times per day.[28] Coffman suggests a 1:4 tincture of the dried root in 40% alcohol, and a dosage of 2-5 ml, 2-3 times per day.[29]  Lust indicates ½-1 teaspoon per dose. 

USAGE

Caution:  May lower blood pressure. [62]



[1] John Lust, Herb Book, 2009, 177.

[2] Andrew Chevallier, Encyclopedia of Herbal Medicine, 2023, 111.

[3] John Lust, Herb Book, 2009, 177.

[4] Fang ZE, et al., Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases, Phytomedicine, 2024 Jan, https://pubmed.ncbi.nlm.nih.gov/37931457/ (accessed 22 July 2025).

[5] Sam Coffman, Herbal Medic, 2014, 232. 

[6] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[7] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[8] Sam Coffman, Herbal Medic, 2014, 232. 

[9] John Lust, Herb Book, 2009, 177.

[10] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[11] John Lust, Herb Book, 2009, 177.

[12] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[13] John Lust, Herb Book, 2009, 177.

[14] Sam Coffman, Herbal Medic, 2014, 232. 

[15] Sam Coffman, Herbal Medic, 2014, 232. 

[16] John Lust, Herb Book, 2009, 177.

[17] John Lust, Herb Book, 2009, 177.

[18] Sam Coffman, Herbal Medic, 2014, 232. 

[19] Sam Coffman, Herbal Medic, 2014, 232. 

[20] Sam Coffman, Herbal Medic, 2014, 232. 

[21] Sam Coffman, Herbal Medic, 2014, 232. 

[22] Sam Coffman, Herbal Medic, 2014, 232. 

[23] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[24] Stephen Harrod Buhner, Herbal Antibiotics, 2012, 372.

[25] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[26] Stephen Harrod Buhner, Herbal Antibiotics, 2012, 372.

[27] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[28] Stephen Harrod Buhner, Herbal Antibiotics, 2012, 372.

[29] Sam Coffman, Herbal Medic, 2014, 232. 

[30]  Yuan R, et al., Alantolactone mitigates the elevation of blood pressure in mice induced by angiotensin II by inhibiting calcium channel activation, BMC Cardiovasc Disord, 2025 Jan 6, Vol 25 No 1, https://pubmed.ncbi.nlm.nih.gov/39762727/ (accessed 22 July 2025).

[31] Lieshchova M, et al., Influence of Inula helenium rhizomes and Matricaria chamomilla inflorescences on the biochemical and physiological parameters in male rats fed a high-fat diet, Rocz Panstw Zakl Hig. 2023, Vol 74 No 4, https://pubmed.ncbi.nlm.nih.gov/38117160/ (accessed 22 July 2025).

[32] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[33] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[34] John Lust, Herb Book, 2009, 177.

[35] Sam Coffman, Herbal Medic, 2014, 232. 

[36] Junhao Li, et al., Isodeoxyelephantopin ameliorates LPS-induced acute peritonitis by inhibiting NLRP3 inflammasome in vitro and in vivo, International Immunopharmacology, Vol 143 No 3, 2024, https://www.sciencedirect.com/science/article/abs/pii/S1567576924016655?via%3Dihub (accessed 22 July 2025).

[37] Sam Coffman, Herbal Medic, 2014, 232. 

[38] John Lust, Herb Book, 2009, 177.

[39] John Lust, Herb Book, 2009, 177.

[40] Sam Coffman, Herbal Medic, 2014, 232. 

[41] John Lust, Herb Book, 2009, 177.

[42] John Lust, Herb Book, 2009, 177.

[43] Sam Coffman, Herbal Medic, 2014, 232. 

[44] John Lust, Herb Book, 2009, 177.

[45] Thomas Easley, et al., Modern Herbal Dispensatory, 2016, 112.

[46] John Lust, Herb Book, 2009, 177.

[47] Sam Coffman, Herbal Medic, 2014, 232. 

[48] John Lust, Herb Book, 2009, 177.

[49] Sam Coffman, Herbal Medic, 2014, 232. 

[50] John Lust, Herb Book, 2009, 177.

[51] John Lust, Herb Book, 2009, 177.

[52] John Lust, Herb Book, 2009, 177.

[53] John Lust, Herb Book, 2009, 177.

[54] John Lust, Herb Book, 2009, 177.

[55] John Lust, Herb Book, 2009, 177.

[56] John Lust, Herb Book, 2009, 177.

[57] Zhang Y, et al., Alantolactone Induced Apoptosis and DNA Damage of Cervical Cancer through ATM/CHK2 Signaling Pathway, Biol Pharm Bull, 2024, Vol 47 No 7, https://pubmed.ncbi.nlm.nih.gov/38972750/ (accessed 22 July 2025).

[58] Lv X, et al., Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway, Pharm Biol, 2023 Dec, Vol 61 No 1, https://pubmed.ncbi.nlm.nih.gov/36994917/ (accessed 22 July 2025).

[59] Huang Y, et al., Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation, Chem Biol Drug Des, 2024 Aug, Vol 104 No 2, https://pubmed.ncbi.nlm.nih.gov/39175059/ (accessed 22 July 2025).

[60] Chun J, Isoalantolactone Suppresses Glycolysis and Resensitizes Cisplatin-Based Chemotherapy in Cisplatin-Resistant Ovarian Cancer Cells, Int J Mol Sci, 2023 Aug 3, Vol 24 No 15, https://pmc.ncbi.nlm.nih.gov/articles/PMC10419319/ (accessed 22 July 2025).

[61] Sung MT, et al., Anticancer potential of isoalantolactone in testicular cancer: an analysis of cytotoxicity, apoptosis, and signaling pathways, Aging (Albany NY), 2024 Oct 9, Vol16 No 19,  https://pmc.ncbi.nlm.nih.gov/articles/PMC11501383/ (accessed 22 July 2025).

[62] Sam Coffman, Herbal Medic, 2014, 232. 

Poppy Seeds for Preparedness Purposes